Brand Name: Tolsikin®
Composition: Tolperisone Hydrochloride 150mg + Diclofenac Sodium 50mg Tablets
Mechanism of action
- Tolperisone: Centrally acts by blocking Na⁺ & Ca²⁺ channels to reduce neuronal excitability. Enhances skeletal muscle blood flow, aiding release of pain-relieving compounds
- Diclofenac: Inhibits COX to reduce inflammation effectively. Concentrates in synovial fluid and inflamed tissues for targeted relief.
Indications
- Acute lower back pain
- Cervical Spondylosis
- Myalgia
- Musculoskeletal Pain Syndromes
References
- Driessen B, Reimann W. Tolperisone: A typical centrally acting muscle relaxant with peripheral action.
- Tekes, Kornelia. "Basic aspects of the pharmacodynamics of Tolperisone, The open medicinal chemistry journal
- Gan TJ. Diclofenac: an update on its mechanism of action and safety profile.