Brand Name: Tolsikin®

Composition: Tolperisone Hydrochloride 150mg + Diclofenac Sodium 50mg Tablets

Mechanism of action

  1. Tolperisone: Centrally acts by blocking Na⁺ & Ca²⁺ channels to reduce neuronal excitability. Enhances skeletal muscle blood flow, aiding release of pain-relieving compounds
  2. Diclofenac: Inhibits COX to reduce inflammation effectively. Concentrates in synovial fluid and inflamed tissues for targeted relief.

Indications

  1. Acute lower back pain
  2. Cervical Spondylosis
  3. Myalgia
  4. Musculoskeletal Pain Syndromes

References

  1. Driessen B, Reimann W. Tolperisone: A typical centrally acting muscle relaxant with peripheral action.
  2. Tekes, Kornelia. "Basic aspects of the pharmacodynamics of Tolperisone, The open medicinal chemistry journal
  3. Gan TJ. Diclofenac: an update on its mechanism of action and safety profile.

Have any query? Our team is just a call away