Benfoplex^®

Brand Name: Benfoplex^®

Composition: Methylcobalamin 1500mcg, Alpha Lipoic acid 100mg, Benfotiamine 150mg, Calcium Carbonate 500mg, Chromium Picolinate 200mcg, Folic acid 1.5mg, Inositol 100mg, Pyridoxine Hydrochloride 3mg, Vitamin D3 1000IU Capsules

BENFOPLEX® supports nerve function and metabolic health with a clinically balanced blend of neuroprotective and antioxidant nutrients.

USP: BENFOPLEX™ combines potent neuro-nutrients with select USP-grade ingredients to support nerve repair, pain relief, and metabolic balance

Mechanism of action (MOA)

1. Methylcobalamin: Active form of Vitamin B12 that aids in nerve regeneration and improves nerve signal transmission1.
2. Alpha Lipoic Acid: A potent antioxidant that reduces oxidative stress, alleviates neuropathic pain, and enhances glucose metabolism
3. Benfotiamine: A fat-soluble form of Vitamin B1 that protects nerves from damage caused by high blood sugar and supports nerve repair
4. Calcium Carbonate: Provides calcium essential for proper nerve impulse transmission and maintaining bone strength
5. Chromium Picolinate: Improves insulin sensitivity, helping regulate blood sugar levels and supporting metabolic health
6. Folic Acid: Vital for DNA synthesis and nerve cell repair, contributing to overall neurological function
7. Inositol: Supports nerve cell communication and plays a role in regulating insulin and metabolic processes
8. Pyridoxine Hydrochloride: Helps synthesize neurotransmitters and reduce symptoms of nerve pain and inflammation
9. Vitamin D3: Enhances nerve health and immune response, supporting nerve regeneration and function

Indications

1. Management of diabetic neuropathy and associated nerve damage.
2. Relief from symptoms of peripheral neuropathy such as pain, tingling, and numbness.
3. Supports nerve health and function.
4. Improves glucose metabolism and insulin sensitivity.
5. Maintains bone health and proper nerve signalling.

References

1. Yagihashi S, et al. "Role of methylcobalamin in diabetic neuropathy." J Diabetes Investig.
2. Ziegler D, et al. "Treatment of symptomatic diabetic polyneuropathy with ALA
3. Stracke H, et al. "Benfotiamine in diabetic polyneuropathy.
4. Clapham DE. "Calcium signalling." Cell.
5. Vincent JB. "The biochemistry of chromium.
6. Craciunescu CN. "Folate in the nervous system."
7. Croze ML, et al. "Therapeutic Potential of Inositol Derivatives in Insulin Resistance.
8. Dakshinamurti K, et al. "Vitamin B6 and the nervous system." Neurosci Biobehav Rev.
9. Annweiler C, et al. "Vitamin D and nerve growth factor in the brain.