Palmiflare®

Brand Name: Palmiflare®

Composition: Palmitoylethanolamide (PEA) (Micronized grade) 300mg, Acetyl L-Carnitine 150mg, Alpha Lipoic acid 50mg, Vitamin E 5mg, Disodium Uridine 5 - Monophosphate Salt 9mg, Cytidine 5 – Monophosphate (CMP) 15mg, Boswellia Serrata Roxb. 50mg Tablets

A Novel, Multi-Targeted Approach to Neuropathic Pain

USP: Micronized PEA for superior absorption, combined with neuroprotective and anti-inflammatory cofactors—targeting multiple pain pathways for safe, effective neuropathic pain relief.

  1. Palmitoylethanolamide (PEA): Micronized PEA offers better absorption; relieves chronic neuropathic and joint pain with analgesic and anti-inflammatory action
  2. Acetyl L-Carnitine: Supports nerve energy metabolism and regeneration, helping reduce muscle fatigue and improve nerve function
  3. Alpha Lipoic Acid: Acts as a powerful antioxidant that protects nerves from oxidative stress and helps manage neuropathic pain
  4. Vitamin E: Protects nerve cells from oxidative damage and helps reduce muscle cramps, supporting overall nerve function and muscle health
  5. Disodium Uridine 5 - Monophosphate (UMP): Supports neuronal membrane synthesis, promotes nerve regeneration, and enhances phospholipid production crucial for nerve integrity
  6. Cytidine 5 Monophosphate (CMP): Aids in neurotransmitter and membrane synthesis. Alongside UMP, it supports nerve repair and helps reduce neuropathic pain
  7. Boswellia Serrata Roxb: Natural 5-LOX inhibitor that reduces nerve and joint inflammation, easing neuropathic and musculoskeletal pain

Indications

  1. Management of chronic neuropathic pain.
  2. Support for nerve regeneration and repair in peripheral neuropathies
  3. Management of specific pain syndromes including fibromyalgia, sciatica, osteoarthritis, lower back pain, migraine, and carpal tunnel syndrome.
  4. Relief from muscle fatigue, cramps.
  5. Alleviation of joint and musculoskeletal pain and inflammation.

References

  1. Petrosino, S., & Di Marzo, V. (2017). The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations.
  2. Sima, A.A.F., et al. (2005). Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy.
  3. Ziegler, D., et al. (2016). Treatment of symptomatic diabetic polyneuropathy with the antioxidant ALA.
  4. Traber, M.G., & Atkinson, J. (2007). Vitamin E, antioxidant and nothing more.
  5. Wurtman, R.J., et al. (2000). Use of uridine and cytidine nucleotides to enhance neuronal membrane synthesis and repair.
  6. Abdel-Tawab, M., et al. (2011). Boswellia serrata

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