Regapin^® NT 400

Brand Name: Regapin^® NT 400

Composition: Gabapentin 400mg + Nortriptyline 10mg Tablets

Mechanism of action (MOA)

1. Gabapentin: Binds to α2–δ subunits of voltage-gated ion channels in CNS, thereby reducing neuronal excitability.
2. Nortriptyline: Inhibits reuptake of norepinephrine and serotonin, thereby enhancing descending inhibitory pathways
3. Evidence-Based Efficacy: Combined therapy showed significantly better response (61.5%) versus mono-therapy (Gabapentin: 38.8%, Nortriptyline: 41.2%) in neuropathic pain.

Indications

1. Diabetic neuropathy
2. Post-herpetic neuralgia
3. Chronic low back pain with neuropathic component

References

1. Yasaei R, Katta S, Patel P, et al. Gabapentin.
2. Merwar G, Gibbons JR, Hosseini SA, et al. Nortriptyline
3. Gilron I, et al. Lancet. 2009;374(9697):1252-1261